abstract：:The background activity of a cortical neural network is modeled by a homogeneous integrate-and-fire network with unreliable inhibitory synapses. For the case of fast synapses, numerical and analytical calculations show that the network relaxes into a stationary state of high attention. The majority of the neurons has ...

journal_title：Journal of computational neuroscience

authors： Kinzel W

更新日期：2008-02-01 00:00:00

abstract：:Avian brain area HVC is known to be important for the production of birdsong. In zebra finches, each RA-projecting neuron in HVC emits a single burst of spikes during a song motif. The population of neurons is activated in a precisely timed, stereotyped sequence. We propose a model of these burst sequences that relies...

journal_title：Journal of computational neuroscience

authors： Jin DZ,Ramazanoğlu FM,Seung HS

更新日期：2007-12-01 00:00:00

abstract：:We investigate the use of extracellular action potential (EAP) recordings for biophysically faithful compartmental models. We ask whether constraining a model to fit the EAP is superior to matching the intracellular action potential (IAP). In agreement with previous studies, we find that the IAP method under-constrain...

journal_title：Journal of computational neuroscience

authors： Gold C,Henze DA,Koch C

更新日期：2007-08-01 00:00:00

abstract：:We study the dynamics and bifurcations of noise-free neurons coupled by gap junctions and inhibitory synapses, using both delayed delta functions and alpha functions to model the latter. We focus on the case of two cells, as in the studies of Chow and Kopell (2000) and Lewis and Rinzel (2003), but also show that stabl...

journal_title：Journal of computational neuroscience

authors： Gao J,Holmes P

更新日期：2007-02-01 00:00:00

abstract：:Rhythmic bursting activity, found in many biological systems, serves a variety of important functions. Such activity is composed of episodes, or bursts (the active phase, AP) that are separated by quiescent periods (the silent phase, SP). Here, we use mean field, firing rate models of excitatory neural network activit...

journal_title：Journal of computational neuroscience

authors： Tabak J,O'Donovan MJ,Rinzel J

更新日期：2006-12-01 00:00:00

abstract：:We construct a neuronal network to model the logic of associative conditioning as revealed in experimental results using the terrestrial mollusk Limax maximus. We show, in particular, how blocking to a previously conditioned stimulus in the presence of the unconditional stimulus, can emerge as a dynamical property of ...

journal_title：Journal of computational neuroscience

authors： Goel P,Gelperin A

更新日期：2006-12-01 00:00:00

abstract：:The precise mapping of how complex patterns of synaptic inputs are integrated into specific patterns of spiking output is an essential step in the characterization of the cellular basis of network dynamics and function. Relative to other principal neurons of the hippocampus, the electrophysiology of CA1 pyramidal cell...

journal_title：Journal of computational neuroscience

authors： Li X,Ascoli GA

更新日期：2006-10-01 00:00:00

abstract：:Nonlinear dynamics provides a complementary framework to control theory for the quantitative analysis of the oculomotor control system. This paper presents a number of findings relating to the aetiology and mechanics of the pathological ocular oscillation jerk congenital nystagmus (jerk CN). A range of time series ana...

journal_title：Journal of computational neuroscience

authors： Akman OE,Broomhead DS,Clement RA,Abadi RV

更新日期：2006-10-01 00:00:00

abstract：:We present a computational study aimed at exploring the sensorimotor cortex modulation of the behaviour of dorsal column nuclei, specifically the impact of synaptic parameters, during both sleep and waking conditions. On the basis of the circuit proposed by Canedo et al. (2000), we have developed realistic computation...

journal_title：Journal of computational neuroscience

authors： Sánchez E,Barro S,Mariño J,Canedo A

更新日期：2006-08-01 00:00:00

abstract：:We have previously formulated an abstract dynamical system for networks of spiking neurons and derived a formal result that identifies the criterion for its dynamics, without inputs, to be "sensitive to initial conditions". Since formal results are applicable only to the extent to which their assumptions are valid, we...

journal_title：Journal of computational neuroscience

authors： Banerjee A

更新日期：2006-06-01 00:00:00

abstract：:This modeling study examines the possible functional roles of two hyperpolarization-activated conductances in lateral superior olive (LSO) principal neurons. Inputs of these LSO neurons are transformed into an output, which provides a firing-rate code for a certain interaural sound intensity difference (IID) range. Re...

journal_title：Journal of computational neuroscience

authors： Szalisznyó K

更新日期：2006-04-01 00:00:00

abstract：:The extraction of the direction of motion from the time varying retinal images is one of the most basic tasks any visual system is confronted with. However, retinal images are severely corrupted by photon noise, in particular at low light levels, thus limiting the performance of motion detection mechanisms of what sor...

journal_title：Journal of computational neuroscience

authors： Shi L,Borst A

更新日期：2006-04-01 00:00:00

abstract：:We have presented a new generation mechanism of slow spiking or repetitive discharges with extraordinarily long inter-spike intervals using the modified Hodgkin-Huxley equations (Doi and Kumagai, 2001). This generation process of slow firing is completely different from that of the well-known potassium A-current in th...

journal_title：Journal of computational neuroscience

authors： Doi S,Kumagai S

更新日期：2005-12-01 00:00:00

abstract：:Computational modeling of dendritic morphology is a powerful tool for quantitatively describing complex geometrical relationships, uncovering principles of dendritic development, and synthesizing virtual neurons to systematically investigate cellular biophysics and network dynamics. A feature common to many morphologi...

journal_title：Journal of computational neuroscience

authors： Donohue DE,Ascoli GA

更新日期：2005-10-01 00:00:00

abstract：:Inhibitory networks are now recognized as being the controllers of several brain rhythms. However, experimental work with inhibitory cells is technically difficult not only because of their smaller percentage of the neuronal population, but also because of their diverse properties. As such, inhibitory network models w...

journal_title：Journal of computational neuroscience

authors： Skinner FK,Bazzazi H,Campbell SA

更新日期：2005-06-01 00:00:00

abstract：:Motivated by experimental observations of the head direction system, we study a three population network model that operates as a continuous attractor network. This network is able to store in a short-term memory an angular variable (the head direction) as a spatial profile of activity across neurons in the absence of...

journal_title：Journal of computational neuroscience

authors： Boucheny C,Brunel N,Arleo A

更新日期：2005-03-01 00:00:00

abstract：:The goal of this paper is to design experiments that confirm the evidence of cognitive responses in functional near infrared spectroscopy and to establish relevant spectral subbands. Hemodynamic responses of brain during single-event trials in an odd-ball experiment are measured by functional near infrared spectroscop...

journal_title：Journal of computational neuroscience

authors： Akgül CB,Sankur B,Akin A

更新日期：2005-01-01 00:00:00

abstract：:We develop a new computationally efficient approach for the analysis of complex large-scale neurobiological networks. Its key element is the use of a new phenomenological model of a neuron capable of replicating important spike pattern characteristics and designed in the form of a system of difference equations (a map...

journal_title：Journal of computational neuroscience

authors： Rulkov NF,Timofeev I,Bazhenov M

更新日期：2004-09-01 00:00:00

abstract：:Wider dissemination and testing of computational models are crucial to the field of computational neuroscience. Databases are being developed to meet this need. ModelDB is a web-accessible database for convenient entry, retrieval, and running of published models on different platforms. This article provides a guide to...

journal_title：Journal of computational neuroscience

authors： Hines ML,Morse T,Migliore M,Carnevale NT,Shepherd GM

更新日期：2004-07-01 00:00:00

abstract：:Waves have long been thought to be a fundamental mechanism for communicating information within a medium and are widely observed in biological systems. However, a quantitative analysis of biological waves is confounded by the variability and complexity of the response. This paper proposes a robust technique for extrac...

journal_title：Journal of computational neuroscience

authors： Robbins KA,Senseman DM

更新日期：2004-05-01 00:00:00

abstract：:We explore the effects of stochastic sodium (Na) channel activation on the variability and dynamics of spiking and bursting in a model neuron. The complete model segregates Hodgin-Huxley-type currents into two compartments, and undergoes applied current-dependent bifurcations between regimes of periodic bursting, chao...

journal_title：Journal of computational neuroscience

authors： Rowat PF,Elson RC

更新日期：2004-03-01 00:00:00

abstract：:The active dendritic conductances shape the input-output properties of many principal neurons in different brain regions, and the various ways in which they regulate neuronal excitability need to be investigated to better understand their functional consequences. Using a realistic model of a hippocampal CA1 pyramidal ...

journal_title：Journal of computational neuroscience

authors： Migliore M,Messineo L,Ferrante M

更新日期：2004-01-01 00:00:00

abstract：:Following a flashed stimulus, I show that a simple neurophysiological mechanism in the primary visual system can generate orientation selectivity based on the first incoming spikes. A biological model of the lateral geniculate nucleus generates an asynchronous wave of spikes, with the most strongly activated neurons f...

journal_title：Journal of computational neuroscience

authors： Delorme A

更新日期：2003-11-01 00:00:00

abstract：:Motoneuron responses were elicited by global visual motion and stepwise displacements of an illuminated stripe. Stimulus protocols were identical to those used in previous behavioral studies of compensatory eyestalk reflexes. The firing rates and directional selectivity of the motoneuron responses were measured with r...

journal_title：Journal of computational neuroscience

authors： Miller CS,Johnson DH,Schroeter JP,Myint L,Glantz RM

更新日期：2003-09-01 00:00:00

abstract：:Purkinje cells aligned on the medio-lateral axis share a large proportion of their approximately 175,000 parallel fiber inputs. This arrangement has led to the hypothesis that movement timing is coded in the cerebellum by beams of synchronously active parallel fibers. In computer simulations I show that such synchrono...

journal_title：Journal of computational neuroscience

authors： Jaeger D

更新日期：2003-05-01 00:00:00

abstract：:Many different neural models have been proposed to account for major characteristics of the memory phenomenon family in primates. However, in spite of the large body of neurophysiological, anatomical and behavioral data, there is no direct evidence for supporting one model while falsifying the others. And yet, we can ...

journal_title：Journal of computational neuroscience

authors： Lorincz A,Szatmáry B,Szirtes G

更新日期：2002-11-01 00:00:00

abstract：:We present a new method to characterize multi-input and output neuronal systems using information theory. To obtain a lower bound of transinformation we take three steps: (1) Estimation of the deterministic response to isolate components carrying stimulus information. The deviation of the original response from the de...

journal_title：Journal of computational neuroscience

authors： Eger M,Eckhorn R

更新日期：2002-05-01 00:00:00

abstract：:The response of leaky integrate-and-fire neurons is analyzed for periodic inputs whose phases vary with their spatial location. The model gives the relationship between the spatial summation distance and the degree of phase locking of the output spikes (i.e., locking to the periodic stochastic inputs, measured by the ...

journal_title：Journal of computational neuroscience

authors： Kuhlmann L,Burkitt AN,Paolini A,Clark GM

更新日期：2002-01-01 00:00:00

abstract：:Information maximization has long been suggested as the underlying coding strategy of the primary visual cortex (V1). Grouping image sequences into blocks has been shown by others to improve agreement between experiments and theory. We have studied the effect of temporal convolution on the formation of spatiotemporal ...

journal_title：Journal of computational neuroscience

authors： Szatmáry B,Lorincz A

更新日期：2001-11-01 00:00:00

abstract：:An analytical model is proposed that can predict the shape of the poststimulus time histogram (PSTH) response to a current pulse of a neuron subjected to uncorrelated background input. The model is based on an explicit description of noise in the form of an escape rate and corresponding hazard function. Two forms of t...

journal_title：Journal of computational neuroscience

authors： Herrmann A,Gerstner W

更新日期：2001-09-01 00:00:00

abstract：:We investigated the effect of mean firing on the information rate of a spiking motion-sensitive neuron in the fly (H1-cell). In the control condition, the cell was stimulated repeatedly by identical zero-symmetrical white-noise motion. The mean firing rate was manipulated by adding a constant velocity offset either in...

journal_title：Journal of computational neuroscience

authors： Borst A,Haag J

更新日期：2001-03-01 00:00:00

abstract：:Much evidence indicates that recognition memory involves two separable processes, recollection and familiarity discrimination, with familiarity discrimination being dependent on the perirhinal cortex of the temporal lobe. Here, we describe a new neural network model designed to mimic the response patterns of perirhina...

journal_title：Journal of computational neuroscience

authors： Bogacz R,Brown MW,Giraud-Carrier C

更新日期：2001-01-01 00:00:00

abstract：:With the advancement in computer technology, it has become possible to fit complex models to neuronal data. In this work, we test how two methods can estimate parameters of simple neuron models (passive soma) to more complex ones (neuron with one dendritic cylinder and two active conductances). The first method uses c...

journal_title：Journal of computational neuroscience

authors： Tabak J,Murphey CR,Moore LE

更新日期：2000-11-01 00:00:00

abstract：:According to a popular hypothesis, short-term memories are stored as persistent neural activity maintained by synaptic feedback loops. This hypothesis has been formulated mathematically in a number of recurrent network models. Here we study an abstraction of these models, a single neuron with a synapse onto itself, or...

journal_title：Journal of computational neuroscience

authors： Seung HS,Lee DD,Reis BY,Tank DW

更新日期：2000-09-01 00:00:00

abstract：:The phase relationship between the activity of hippocampal place cells and the hippocampal theta rhythm systematically processes as the animal runs through the region in an environment called the place field of the cell. We present a minimal biophysical model of the phase precession of place cells in region CA3 of the...

journal_title：Journal of computational neuroscience

authors： Bose A,Booth V,Recce M

更新日期：2000-07-01 00:00:00

abstract：:The classical view of cortical information processing is that of a bottom-up process in a feedforward hierarchy. However, psychophysical, anatomical, and physiological evidence suggests that top-down effects play a crucial role in the processing of input stimuli. Not much is known about the neural mechanisms underlyin...

journal_title：Journal of computational neuroscience

authors： Siegel M,Körding KP,König P

更新日期：2000-03-01 00:00:00

abstract：:Activation of calcium/calmodulin-dependent protein kinase II (CaMKII) by calmodulin following calcium entry into the cell is important for long-term potentiation (LTP). Here a model of calmodulin binding and trapping by CaMKII in a dendritic spine was used to estimate levels and durations of CaMKII activation followin...

journal_title：Journal of computational neuroscience

authors： Holmes WR

更新日期：2000-01-01 00:00:00

abstract：:Can one develop an abstract description of the dynamics of pattern generators that provides quantitative insight into their operation? We explored this question by examining the dynamics of a model central pattern generator that was created using an evolutionary algorithm. We propose an abstract description based on t...

journal_title：Journal of computational neuroscience

authors： Chiel HJ,Beer RD,Gallagher JC

更新日期：1999-09-01 00:00:00

abstract：:We have developed compact analog integrated circuits that simulate two synaptic excitatory conductances. A four-transistor circuit captures the dynamics of an excitatory postsynaptic current caused by a real AMPA conductance. A six-transistor circuit simulates the effects of a real voltage-dependent NMDA conductance. ...

journal_title：Journal of computational neuroscience

authors： Rasche C,Douglas RJ

更新日期：1999-07-01 00:00:00

abstract：:We consider whole-cell voltage-clamp data of isolated currents characterized by the Hodgkin-Huxley paradigm. We examine the errors associated with the typical parameter estimation method for these data and show them to be unsatisfactorally large especially if the time constants of activation and inactivation are not s...

journal_title：Journal of computational neuroscience

authors： Willms AR,Baro DJ,Harris-Warrick RM,Guckenheimer J

更新日期：1999-03-01 00:00:00